Nicotine and Sperm

Sperm and Nicotine

World J Mens Health. 2024 Jul 11;43(2):291–303. doi: 10.5534/wjmh.240072

Adverse Effects of Nicotine on Human Sperm Nuclear Proteins

Amir Masoud Firouzabadi 1, Ralf Henkel 2,3,4, Maryam Tofighi Niaki 5, Farzaneh Fesahat 1,✉

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PMCID: PMC11937351  PMID: 39028130

 

 

 

 

In males, nicotine affects the testes where prolonged exposure changes the morphology of spermatogenic cells, reduces sperm production, decreased steroidogenesis and inhibits spermatogenesis resulting in decreased sperm counts, poor sperm motility and increased levels of DNA damage [20,21]. Early ejaculation and a diminished penile erection are additional negative consequences of nicotine intake; however, they vary depending on individual sensitivity or susceptibility [22].